Improved recombinant hepatitis b surface antigen

Details Improved recombinant hepatitis b surface antigen Improved recombinant hepatitis b surface antigen

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) A61K 45/00 (2006.01) C07K 14/00 (2006.01) C07K 14/02 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2355680

The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and combination vaccines which produce and protective immunization against infection by hepatitis B virus and other infectious agents.

La présente invention concerne un antigène d'enveloppe d'hépatite B de recombinaison amélioré qui présente un pouvoir antigénique supérieur par rapport aux antigènes de l'art antérieur. L'invention a également pour objet un procédé de fabrication d'un antigène d'enveloppe d'hépatite B de recombinaison amélioré. Ce dernier permet d'obtenir des vaccins avec de faibles quantités d'ingrédients actifs, des vaccins avec un fort pouvoir antigénique et des vaccins de combinaison qui produisent une immunisation protectrice contre l'infection par le virus de l'hépatite B et autres agents infectieux.

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