Pyrazole-amides and -sulfonamides

Details Pyrazole-amides and -sulfonamides Pyrazole-amides and -sulfonamides

C - Chemistry, Metallurgy

07

D

C07D 231/10 (2006.01) A61K 31/415 (2006.01) C07D 231/14 (2006.01) C07D 231/40 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2465207

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Composés, compositions et procédés utiles dans le traitement de diverses maladies par l'inhibition du flux d'ions de sodium circulant par les canaux sodiques dépendants de la tension. Elle concerne notamment des pyrazole-amides et -sulfonamides, des compositions et procédés utiles dans le traitement des troubles des systèmes nerveux central et périphérique, en particulier de la douleur et de la douleur chronique, par le blocage des canaux sodiques associés au début ou à la récurrence des états mentionnés ici. Les composés, compositions et procédés de la présente invention sont particulièrement utiles pour le traitement de la douleur neuropathique et inflammatoire par l'inhibition du flux d'ions passant par un canal qui comprend une sous-unité de PN3.

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