A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/32 (2006.01) A61F 2/30 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01)
Patent
CA 2247158
The present invention relates to methods of making and/or repairing cartilage in vivo comprising implanting into a patient, at a site of cartilage damage or loss, a biocompatible, non-living three-dimensional scaffold or framework structure in combination with periosteal/perichondrial tissue that can be used to hold the scaffold in place and provides a source of chondrocyte progenitor cells, chondrocytes and other stromal cells for attachment to the scaffold in vivo. In addition, a preparation of cells that can include chondrocytes, chondrocyte progenitor cells or other stromal cells is administered, either before, during or after implantation of the scaffold and/or the periosteal perichondrial tissue; the cells are administered directly into the site of the implant in vivo and promote the induction of factors that enhance chondrogenesis and the migration of chondrocytes, progenitor cells and other stromal cells from the adjacent in vivo environment into the scaffold for the production of new cartilage at the site of implantation.
La présente invention concerne des méthodes de fabrication et/ou de réparation de cartilage in vivo comportant l'implantation, dans un site où le cartilage est endommagé ou perdu, d'un support ou structure tridimensionnelle biocompatible et non vivante en association avec du tissu périostatique/périchondral qui peut être utilisé pour tenir le support en place et servir de source de cellules souches de chondrocytes, de chondrocytes et d'autres cellules du stroma à fixer au support in vivo. Une préparation de cellules pouvant contenir des chondrocytes, des cellules souches de chondrocytes ou d'autres cellules du stroma est de plus administrée, soit avant, pendant ou après la greffe du support et/ou du tissu périostique/périchondral; les cellules sont administrées directement dans le site de l'implant in vivo et favorisent l'induction de facteurs qui accélèrent la chondrogenèse et la migration de chondrocytes, de cellules souches et d'autres cellules du stroma du milieu adjacent in vivo vers le support pour la production de nouveau cartilage au site de la greffe.
Naughton Gail K.
Willoughby Jane
Advanced Tissue Sciences Inc.
Borden Ladner Gervais Llp
T. J. Smith & Nephew Limited
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