4e-bp3, a new member of the eukaryotic initiation factor...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238217

The present invention relates to the process of protein synthesis in eukaryotic cells. More particularly, the present invention relates to translation and more specifically to the initiation of translation in such cells. More specifically, the present invention relates to proteins involved in the initiation of translation in animal cells, to the modulation of translation thereby and to the interaction and sequestering of a limiting factor of initiation of translation, elF-4E. The present invention also relates to isolated nucleic acid molecules encoding a human protein, a 4E-binding protein (4E-BP3), as well as vectors and host cells harboring same. In addition, the present invention relates to screening assays for identifying modulators of 4E-BP3 activity and to the identification of mutants thereof which abrogate its interaction with elF-4E.

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