Novel hiv-specific synthetic oligonucleotides and methods of...

Details Novel hiv-specific synthetic oligonucleotides and methods of... Novel hiv-specific synthetic oligonucleotides and methods of...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2300352

Disclosed are synthetic oligonucleotides having a nucleotide sequence specifically complementary to nucleotides 324 to 345 of a conserved gag region of the HIV-1 genome, the oligonucleotide consisting of 21 nucleotides which are linked via phosphorothioate internucleotide linkages. Also disclosed are methods for inhibiting and treating HIV-1 and HIV-2 infection.

L'invention concerne des oligonucléotides synthétiques présentant une séquence nucléotidique spécifiquement complémentaire des nucléotides 324 à 345 de la région gag conservée du génome du VIH-1, l'oligonucléotide se composant de 21 nucléotides lesquels sont liés par des liaisons internucléotidiques phosphorothioate. L'invention concerne également des méthodes d'inhibition et de traitement d'infections à VIH-1 et VIH-2.

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