C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/34 (2006.01)
Patent
CA 2520740
Present invention refers to the process of preparing amorphous atorvastatin calcium without intermediate isolation of crystal or undefined mixture of crystal and amorphous atorvastatin calcium, respectively. Forming of calcium atorvastatin salt is carried out in a mixture of chlorinated organic solvent or cyclic hydrocarbon solvent, respectively, the non-hydroxylic organic solvent, and water, the source of calcium ions is calcium acetate or calcium chloride, respectively.
La présente invention se rapporte à un procédé de préparation d'atorvastatine calcique amorphe, sans isolation intermédiaire d'un cristal ou d'un mélange indéfini de cristal et d'atorvastatine calcique, respectivement. Un sel d'atorvastatine calcique est formé dans un mélange contenant un solvant organique chloré ou un solvant hydrocarboné cyclique, respectivement, un solvant organique non hydroxylique, et de l'eau, la source d'ions calcium étant de l'acétate de calcium ou du chlorure de calcium, respectivement.
Antoncic Ljubomir
Copar Anton
Sorsak Gorazd
Goudreau Gage Dubuc
Lek Pharmaceuticals D.d.
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