C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/4178 (2006.01) A61P 31/18 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2618566
Certain 1H-indole-2-carboxylates and -2-carboxamides are HIV reverse transcriptase inhibitors. These indole compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
L'invention porte sur certains 1H-indole-2-carboxylates et -2-carboxamides qui sont des inhibiteurs de la transcriptase inverse. Les composés indoles précités et leurs sels pharmaceutiquement acceptables sont utilisés pour inhiber la transcriptase inverse du VIH, pour la prophylaxie et le traitement de l'infection à VIH et pour la prophylaxie et le traitement du SIDA ou pour en retarder l'apparition. Les composés précités et leurs sels peuvent être utilisés comme ingrédients dans des compositions pharmaceutiques, facultativement combinés à d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.
Williams Theresa M.
Zhang Xu-Fang
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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