Limbic system-associated membrane protein and dna

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216842

The present invention is directed to nucleic acid sequences encoding a limbic- system associated membrane protein ("LAMP") and to purified proteins with LAMP activity. LAMP is a self-binding, antibody-like cell surface adhesion protein, the presence of which on one neuron of the limbic system stimulates the formation of connections with adjacent neurons. The invention provides a nucleic acid encoding a polypeptide with at least about 90 % homology to a LAMP self-binding domain, and corresponding proteins. The invention also provides nucleic acids that hybridize to LAMP-encoding nucleic acids.

La présente invention concerne des séquences nucléotidiques qui codent une protéine membranaire associée au système limbique ("LAMP"), et des protéines purifiées ayant une activité "LAMP". Une "LAMP" est une protéine adhérant aux surfaces de cellules, analogue à un anticorps et à auto-liaison. Sa présence sur un neurone du système limbique stimule la formation de connexions avec des neurones voisins. L'invention concerne un acide nucléique qui code un polypeptide présentant une homologie d'au moins environ 90 % avec un domaine de "LAMP" à auto-liaison, et les protéines correspondantes. L'invention concerne également des acides nucléiques qui s'hybrident avec des acides nucléiques codant des "LAMP".

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