New substituted amides, their production and their use

Details New substituted amides, their production and their use New substituted amides, their production and their use

C - Chemistry, Metallurgy

07

C

C07C 237/36 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 237/32 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2328396

The invention relates to cysteine protease inhibitors of the general formula (I), in which A is -(CH2)p-R1, where R1 can be pyrrolidine, morpholine, piperidine, -NR5R6 and formula (a) and p can be 1 or 2; B can be possibly substituted phenyl, pyridyl, pyrimidyl and pyridazyl; D is a bond, -(CH2)m-, -CH=CH-, -C.ident.C-; R2 is chlorine, bromine, fluorine, alkyl, NHCO alkyl, NHSO2 alkyl, N02, -O-alkyl and NH2; R3 is an alkyl which can carry a possibly substituted phenyl ring, indolyl ring and cyclohexyl ring; and Y is phenyl, pyridine, pyrimidine and pyrazine; R4 is hydrogen, COOR9 and CO-Z, where Z is NR10R11 and and formula (b); n is 0, 1 or 2 and m is 0, 1, 2, 3 or 4.

L'invention concerne des inhibiteurs de protéase de cystéine de la formule (I). A représente -(CH2)p-R<1>, où R<1> peut être de la pyrrolidine, de la morpholine, de la pipéridine, -NR<5>R<6> et la formule (a) et p vaut 1 ou 2; B représente phényle, pyridyle, pyrimidyle et pyridazyle éventuellement substitués; D représente une liaison, -(CH2)m-, -CH=CH-, -CC-; R<2> représente du chlore, brome, fluor, alkyle, NHCO-alkyle, NHSO2-alkyle, NO2, -O-alkyle et NH2; R<3> représente alkyle, pouvant également porter un cycle phényle, un cycle indolyle et un cycle cyclohexyle éventuellement substitués; Y représente phényle, pyridine, pyrimidine et pyrazine; R<4> représente COOR<9> et CO-Z NR<10>R<11>, et formule (b); n vaut 0, 1 ou 2 et m vaut 0, 1, 2, 3 ou 4.

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