Treatment of insulin resistance

Details Treatment of insulin resistance Treatment of insulin resistance

C - Chemistry, Metallurgy

12

N

C12N 15/17 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/28 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/72 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223891

Methods and compositions are provided for the treatment of insulin-resistance through the inhibition of protein kinase C-mediated phosphorylation of the amino acid residue Ser1270 of the insulin receptor. Methods for testing candidate compounds suitable for inhibition of serine-phosphorylation by protein kinase C are also provided.

L'invention concerne des procédés et des compositions pour le traitement de l'insulinorésistance par l'inhibition de la phosphorylation, induite par la protéine kinase C, du reste d'acide aminé Ser¿1270? du récepteur à l'insuline. L'invention concerne également des procédés pour tester des composés potentiels aptes à inhiber la phosphorylation de la sérine assurée par la protéine kinase C.

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