A new metastatic human tumor associated molecule, methods to...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C12N 5/16 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2713193

This disclosure characterizes the function and the expression of the human protein encoded by tm9sf4. The protein is highly expressed in malignant tumor cells and therefore is a novel marker for malignancy. Moreover, the protein is involved in the phagocytotic character of tumor cells. This disclosure provides methods and tools to diagnose and follow up malignancy of tumors. Furthermore, means to inhibit phagocytotic character of tumor cells as well as means to treat cancer are provided.

Cette invention concerne la fonction et l'expression de la protéine humaine codée par tm9sf4. La protéine est exprimée à un niveau élevée dans des cellules tumorales malignes, et est par conséquent un nouveau marqueur de la malignité. En outre, la protéine joue un rôle dans le caractère phagocytotique des cellules tumorales. Cette invention porte par conséquent sur des procédés et sur des outils pour le diagnostic et le suivi de la malignité des tumeurs. En outre, cette invention porte sur des moyens d'inhibition du caractère phagocytotique des cellules tumorales, ainsi que sur des moyens pour traiter le cancer.

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