Shelf stable aspirin solutions

Details Shelf stable aspirin solutions Shelf stable aspirin solutions

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 9/08 (2006.01) A61K 9/12 (2006.01) A61K 47/12 (2006.01) A61K 47/16 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2064035

2064035 9101761 PCTABS00003 There is provided a shelf stable solution of aspirin, free of moieties reactive with aspirin, suitable for topical application to the skin compounded from aspirin, N,N-diethyl-m-toluamide USP (DEET), glyceryl triacetate USP (GTA), and acetic anhydride, provided that where GTA is present, at least 20 parts of DEET shall also be present and, after all components shall have been mixed, the resultant solution shall contain an initial amount of between about 1 and about 0.2 parts of acetic anhydride. The solution is made by preparing a solvent component consisting of at least N,N-diethyl-m-toluamide USP (DEET), and, if desired, glyceryl triacetate USP (GTA), provided that where GTA is present, at least 20 parts of DEET shall also be present, assaying said solvent mixture to determine the hydroxyl content, adding sufficient acetic anhydride to provide between about 1 to about 0.2 parts of unreactive acetic anhydride in the solution after dissolution of the aspirin therein, and dissolving aspirin, thereinto.

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