Nucleic acids encoding (poly)peptides having chips activity

Details Nucleic acids encoding (poly)peptides having chips activity Nucleic acids encoding (poly)peptides having chips activity

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/04 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 39/085 (2006.01) A61P 37/02 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2395876

The invention relates to nucleic acid molecules encoding (poly)peptides having chemotaxis inhibiting polypeptides CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having CHIPS activity and to the use of such recombinant (poly)peptides having CHIPS activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions and HIV. In addition the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity.

L'invention concerne des molécules d'acide nucléique codant pour des (poly)peptides ayant une activité de CHIPS (Chemotaxis Inhibitory Protein from Staphylococcus aureus), des vecteurs recombinés hébergeant de telles molécules, et les cellules hôtes portant ces vecteurs. L'invention concerne également des méthodes pour préparer des (poly)peptides recombinant ayant une activité de CHIPS et l'utilisation de tels (poly)peptides recombinant ayant une activité de CHIPS à des fins de diagnostic, de prophylaxie et de traitement, tel que le traitement de réactions inflammatoires et du VIH. L'invention concerne en outre des compositions thérapeutiques et diagnostiques comprenant comme agent actif le (poly)peptide ayant une activité de CHIPS.

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