Methods for identification of tumor phenotype and treatment

Details Methods for identification of tumor phenotype and treatment Methods for identification of tumor phenotype and treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2742489

The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a future date, methods of treating an ERGO tumor in a patient, and methods of selecting patients diagnosed as ERGO tumor prostate cancer patients for aggressive clinical treatment. The methods of the disclosure are applicable to ERGO tumors present in different human organs and tissues such as breast, lung, thyroid, ovary, and prostate.

L'invention porte sur des procédés pour identifier une tumeur en tant que tumeur surexprimant le gène sensible à E2F (ERGO), sur des procédés de détermination de la probabilité qu'un patient atteint d'une tumeur ERGO survivra à une date future, sur des procédés de traitement d'une tumeur ERGO chez un patient, et sur des procédés de sélection de patients diagnostiqués comme patients atteints de cancer de la prostate à tumeur ERGO pour un traitement clinique agressif. Les procédés de la description sont applicables à des tumeurs ERGO présentes dans différents organes et tissus humains tels que le sein, le poumon, la thyroïde, les ovaires et la prostate.

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