A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/65 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2316972
Chemically modified tetracyclines are a new class of non-steroidal anti- inflammatory drugs which inhibit cyclooxygenase-2 and tumor necrosis factor alpha. These chemically modified tetracyclines are used in a method for inhibiting COX-2, which in turn inhibits PGE2, and/or inhibiting TNF.alpha.. They are also used in a method for treating a disease or disorder associated with elevated activities of COX-2 (i.e., increased production of PGE2) and/or TNF.alpha..
L'invention concerne des tétracyclines modifiées chimiquement constituant une nouvelle classe de médicaments anti-inflammatoires non stéroïdiens qui inhibent la cyclooxygénase-2 et le facteur de nécrose des tumeurs alpha. On utilise ces tétracyclines modifiées chimiquement sont utilisée dans une méthode permettant d'inhiber la COX-2, laquelle entraîne à son tour une inhibition de la PGE2, et/ou d'inhiber le TNF alpha . On les utilise également dans le traitement de maladies ou de troubles associés à une activité accrue de COX-2 (donc à une production accrue de PGE2) et/ou de TNF alpha .
Abramson Steven
Amin Ashok
Borden Ladner Gervais Llp
New York University
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