Immunoglobin-like domains with increased half lives

Details Immunoglobin-like domains with increased half lives Immunoglobin-like domains with increased half lives

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2249195

Disclosed are recombinant vectors encoding immunoglobulin-like domains and portions thereof, such as antibody Fc-hinge fragments, subfragments and mutant domains with extended biological half lives. Methods of producing large quantities of such domains, heterodimers, and fusion proteins following expression by host cells are also reported. Described are antibody Fc and Fc- hinge domains, which have the same in vivo stability as intact antibodies; and domains engineered to have increased in vivo half lives. These DNA constructs and protein domains will be useful as templates for in vitro mutagenesis and high resolution structural studies; for immunization and vaccination; and for the production of recombinant antibodies or chimeric proteins with increased stability and longevity for therapeutic and diagnostic uses.

Vecteurs recombinants codant des domaines analogues à l'immunoglobuline et des parties de ces derniers, tels que des domaines mutants, des sous-fragments et des fragments de Fc-charnière (Fc-hinge) anticorpaux, à demi-vies biologiques prolongées. Des procédés de production en grandes quantités de tels domaines, hétérodimères et protéines fusionnées après leur expression par des cellules hôtes sont également décrits, ainsi que des domaines Fc et Fc-charnière anticorpaux, qui présentent la même stabilité in vivo que les anticorps intacts; et des domaines génétiquement modifiés de façon à présenter des demi-vies in vivo prolongées. Ces ADN de recombinaison et ces domaines protéiques seront utiles comme matrices pour la mutagenèse in vitro et pour les études de structures de haute résolution; pour l'immunisation et la vaccination; ainsi que pour la production d'anticorps recombinants ou de protéines chimériques à stabilité et longévité accrue destinés à des usages thérapeutiques et diagnostiques.

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