Method of affecting cholesterol catabolism using nuclear...

Details Method of affecting cholesterol catabolism using nuclear... Method of affecting cholesterol catabolism using nuclear...

C - Chemistry, Metallurgy

40

B

C40B 30/00 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01) C07G 99/00 (2009.01)

Patent

CA 2368234

The present invention relates to methods and compositions for modulating genes which are controlled by the FXR orphan nuclear hormone receptor. In a preferred embodiment, the method involves modulation of the gene encoding Cyp7a, the enzyme responsible for a major pathway in the elimination of cholesterol. The invention also relates to methods for screening compounds which bind to and activate or inhibit the FXR nuclear hormone receptor.

La présente invention concerne des procédés et des compositions permettant de moduler des gènes régulés par le récepteur d'hormones nucléaires orphelines FXR. Selon un mode de réalisation préféré, le procédé consiste en la modulation du gène codant Cyp7a, l'enzyme responsable du mécanisme principal dans l'élimination du cholestérol. L'invention concerne également des procédés de criblage des composés qui se fixent à et activent ou inhibent le récepteur d'hormones nucléaires FXR.

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