Foxp3 peptide vaccine

Details Foxp3 peptide vaccine Foxp3 peptide vaccine

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2674365

The present invention provides Foxp3 peptides comprising the amino acid sequence of SEQ ID NOs: 3-5, 7-9, 12, 15-19, 22, 24, 27-30, 37, 67 or 74, and Foxp3 peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility, and also provides drugs for regulating regulatory T cells comprising these Foxp3 peptides. The Foxp3 peptides of this invention find use as vaccines.

La présente invention concerne des peptides Foxp3 qui se composent d'une séquence d'acides aminés de numéros d'ID de séquence suivantes : 3-5, 7-9, 12, 15-19, 22, 24, 27-30, 37, 67 ou 74, et des peptides Foxp3 se composant de séquences d'acides aminés mentionnés ci-dessus dans lesquelles 1, 2 ou plusieurs acides aminés sont substitués ou ajoutés, et qui ont une inductibilité de cellule T cytotoxique et aussi qui propose des médicaments pour réguler les cellules T régulatrices comprenant ces peptides Foxp3. Les peptides Foxp3 de cette invention sont utilisés dans des vaccins.

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