C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/02 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 207/06 (2006.01) C07D 211/14 (2006.01) C07D 233/02 (2006.01) C07D 239/04 (2006.01) C07D 241/04 (2006.01) C07D 249/04 (2006.01) C07D 251/04 (2006.01) C07D 257/04 (2006.01) C07D 257/08 (2006.01) C07D 265/06 (2006.01) C07D 265/28 (2006.01) C07D 273/01 (2006.01) C07D 273/04
Patent
CA 2263925
This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
L'invention porte sur des esters et amides hétérocycliques neurotrophiques de faible poids moléculaire et à petites molécules présentant une affinité pour les immunophilines de type FKBP, et sur leur utilisation comme inhibiteurs de l'activité enzymatique associée aux protéines d'immunophiline et en particulier à l'activité enzymatique des peptidyl et prolyl isomérases ou rotamases.
Hamilton Gregory S.
Li Jia-He
Gpi Nil Holdings Inc.
Guilford Pharmaceuticals Inc.
Ridout & Maybee Llp
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