Heterocyclic esters and amides

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 267/02 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 207/06 (2006.01) C07D 211/14 (2006.01) C07D 233/02 (2006.01) C07D 239/04 (2006.01) C07D 241/04 (2006.01) C07D 249/04 (2006.01) C07D 251/04 (2006.01) C07D 257/04 (2006.01) C07D 257/08 (2006.01) C07D 265/06 (2006.01) C07D 265/28 (2006.01) C07D 273/01 (2006.01) C07D 273/04

Patent

CA 2263925

This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

L'invention porte sur des esters et amides hétérocycliques neurotrophiques de faible poids moléculaire et à petites molécules présentant une affinité pour les immunophilines de type FKBP, et sur leur utilisation comme inhibiteurs de l'activité enzymatique associée aux protéines d'immunophiline et en particulier à l'activité enzymatique des peptidyl et prolyl isomérases ou rotamases.

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