C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/04 (2006.01) A61K 31/357 (2006.01) A61P 1/16 (2006.01)
Patent
CA 2761656
The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prevention of liver diseases, preferably for the treatment of viral hepatitis, e.g. hepatitis B or C, in particular in a patient who will undergo or has undergone liver transplantation. Preferably, the amorphous silibinin is adapted for oral administration.
L'invention concerne un procédé pour la préparation de silibinine amorphe (ou ses synonymes : silybine ou silibine) issue d'un extrait de fruit de chardon-Marie dont la vitesse de libération est augmentée et dont l'aptitude à l'absorption ou la biodisponibilité est améliorée, et l'utilisation de silibinine amorphe pour le traitement ou la prévention de maladies hépatiques, de préférence pour le traitement d'une hépatite virale, par exemple de l'hépatite B ou C, en particulier chez un patient qui va subir ou qui a subi une transplantation hépatique. De préférence, la silibinine amorphe est conçue pour une administration orale.
Mengs Ulrich
Nagell Astrid
Pohl Ralf-Torsten
Rovati Lucio Claudio
Rull Prous Santiago
Euromed S.a.
Fetherstonhaugh & Co.
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