Diagnosis of human kidney diseases

G - Physics – 01 – N

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G01N 33/50 (2006.01) A61K 31/16 (2006.01) A61K 31/164 (2006.01) A61K 31/4412 (2006.01) A61K 31/4422 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2371242

Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.

L'invention concerne le diagnostic de maladies du rein chez l'humain par la mesure du fer catalytique urinaire. On traite les maladies progressives du rein en administrant aux humains un chélateur du fer. On peut notamment stopper l'évolution d'une maladie du rein en particulier, et en atténuer sa gravité en administrant des chélateurs du fer aux humains atteints d'une maladie progressive du rein. Les procédés de l'invention consistent à mesurer la teneur en fer catalytique dans l'urine d'un individu atteint d'une maladie progressive du rein et à lui administrer un chélateur du fer. Le procédé peut également consister à mesurer, avant, pendant ou après l'administration du chélateur du fer, la teneur urinaire totale en protéines, la créatinine ou l'azote uréique du sang dans un échantillon de sang.

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