(3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid...

Details (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid... (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid...

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01)

Patent

CA 2658986

The present invention relates to (3-amino-l,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

La présente invention concerne des dérivés de l'acide (3-amino-1,2,3,4-tétrahydro-9H-carbazol-9-yl)-acétique de la Formule I (I) dans laquelle R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, et leur utilisation en tant que modulateurs des récepteurs de la prostaglandine, plus particulièrement comme modulateurs des récepteurs de la prostaglandine D2, dans le traitement de diverses maladies et troubles à médiation par la prostaglandine. La présente invention concerne également des compositions pharmaceutiques contenant ces composés et des procédés permettant de les préparer.

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