Assembly-deficient herpesvirus vaccine

Details Assembly-deficient herpesvirus vaccine Assembly-deficient herpesvirus vaccine

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/245 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 9/50 (2006.01)

Patent

CA 2261071

A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virion particles. The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal.

Vaccin qui contient un herpesvirus à déficience d'assemblage. Ledit herpesvirus mutant est capable d'infecter les cellules d'un mammifère susceptible et de subir une réplication de l'ADN dans lesdites cellules, mais il présente une déficience pour ce qui est de l'assemblage du capside et la formation de virion matures. Ledit herpesvirus est avirulent et est capable de produire une réponse immunitaire chez un mammifère vacciné.

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