Method of identifying a ligand for a target molecule

Details Method of identifying a ligand for a target molecule Method of identifying a ligand for a target molecule

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 17/14 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2392797

Ligands that interact with a target, such as one present on a virus, can be more easily identified if false positive interactions (either specific or non- specific) are differentiated from the target-specific interaction. An improved method for screening a library of surface-immobilized ligands which bind to a target is presented. The method can be used for multiple screenings of the same surface-immobilized library for a number of different ligands.

L'invention porte sur des ligands ayant une interaction avec une cible, par exemple, une cible pr~sente sur un virus, et pouvant Útre plus facilement identifi~s si de fausses interactions positives (sp~cifiques ou non sp~cifiques) se diff~rencient de l'interaction sp~cifique d'une cible. L'invention porte ~galement sur un proc~d~ de recherche syst~matique d'une banque de ligands immobilis~s sur une surface et se fixant ~ une cible. Ce proc~d~ peut Útre utilis~ dans plusieurs recherches syst~matiques de la mÚme banque immobilis~e sur une surface pour un nombre de ligands diff~rents.

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