Solubilized topoisomerase poison agents

Details Solubilized topoisomerase poison agents Solubilized topoisomerase poison agents

C - Chemistry, Metallurgy

07

D

C07D 491/147 (2006.01) A61K 31/4375 (2006.01) A61K 31/5025 (2006.01) C07D 491/14 (2006.01)

Patent

CA 2467279

The invention provides compounds of formula (I): wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

L'invention concerne des composés de formule (I): dans laquelle A, B, W, Y, Z et R<sb>1</sb> ont les significations définies dans la description et les sels acceptables sur le plan pharmaceutique de ceux-ci. L'invention concerne également des compositions pharmaceutiques comprenant un composé de formule I, des procédés de préparation des composés de formule I, des intermédiaires utiles pour la préparation des composés de formule I et des méthodes thérapeutiques permettant de traiter un cancer au moyen des composés de formule I.

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