New chemokines expressed in pancreas

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2209227

The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisens molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2- encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2- encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.

La présente invention se rapporte à des séquences nucléotidiques et d'acides aminés qui identifient et codent de nouvelles chémokines exprimées (PANEC-1 et PANEC-2) provenant des cellules pancréatiques humaines. L'invention se rapporte également à des molécules antisens par rapport aux séquences nucléotidiques qui codent les chémokines PANEC-1 et PANEC-2, à des vecteurs d'expression destinés à la production de PANEC-1 et PANEC-2 purifiées, à des anticorps capables de se lier spécifiquement aux PANEC-1 et PANEC-2, à des oligonucléotides ou sondes d'hybridation destinés à la détection de séquences nucléotidiques codant les PANEC-1 et PANEC-2, à des cellules hôtes génétiquement modifiées pour exprimer les PANEC-1 et PANEC-2, et à des essais diagnostiques relatifs à l'activation des chémokines, où interviennent des molécules d'acide nucléique codant les PANEC-1 et PANEC-2 et des anticorps capables de se lier spécifiquement à la protéine.

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