Use of 2-methylene-19-nor-20(s)-1.alpha.,25-dihydroxyvitamin...

Details Use of 2-methylene-19-nor-20(s)-1.alpha.,25-dihydroxyvitamin... Use of 2-methylene-19-nor-20(s)-1.alpha.,25-dihydroxyvitamin...

A - Human Necessities

61

K

A61K 31/593 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2556931

This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)- 1.alpha.,25, dihydroxyitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements, as well as use by normal subjects when high bone mass is desired.

Cette invention porte sur des utilisations pharmaceutiques de 2-méthylène-19-nor-20(S)-1?,25, dihydroxyitamine D¿3?. Ce composé est caractérisé par une activité préférentielle sur l'os telle qu'une haute activité de mobilisation du calcium dans l'os. Ce composé permet d'obtenir un nouvel agent thérapeutique destiné au traitement et à la prophylaxie de maladies au cours desquelles une formation osseuse est souhaitable, en particulier l'ostéoporose. Ce composé augmente également la résistance aux fractures et la résistance à l'écrasement des os, prouvant ainsi son utilisation conjointement avec la chirurgie prothétique osseuse telle que les prothèses de hanche et de genou, et également son utilisation chez des sujets en bonne santé souhaitant obtenir une masse osseuse plus élevée.

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