Methods of treating diabetes using pde 11a inhibitors

Details Methods of treating diabetes using pde 11a inhibitors Methods of treating diabetes using pde 11a inhibitors

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/00 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 15/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2477832

Methods of the invention relate to treatment of diabetes, particularly type 2 diabetes, and related disorders by administration of a PDE11A inhibitor. Such PDE11A inhibitors may be administered in conjunction with alpha-glucosidase inhibitors, insulin sensitizers, insulin secretagogues, hepatic glucose output lowering compounds, beta3 agonist or insulin. Such PDE11A inhibitors may also be administered in conjunction with body weight reducing agents. Further methods of the invention relate to stimulating insulin release from pancreatic cells, particularly in response to an elevation in blood glucose concentration, by administration of a PDE11A inhibitor.

L'invention concerne des procédés relatifs au traitement du diabète, en particulier le diabète de type 2, y compris les troubles connexes, par administration d'un inhibiteur de PDE11A. Ce type d'inhibiteur peut être administré en combinaison avec des inhibiteurs d'alpha-glucosidase, des sensibilisateurs à l'insuline, des sécrétagogues d'insuline, des composés abaissant la glycogénolyse hépatique, un bêta3-agoniste ou de l'insuline, mais aussi des agents de réduction pondérale. L'invention concerne également des procédés relatifs à la stimulation de la libération d'insuline par les cellules pancréatiques, en particulier suite à une élévation de la glycémie, par administration d'un inhibiteur de PDE11A.

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