Spontaneously dispersible pharmaceutical compositions

Details Spontaneously dispersible pharmaceutical compositions Spontaneously dispersible pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/27 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2578854

A spontaneously dispersible pharmaceutical composition comprising a poorly soluble drug and a carrier medium comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic component, wherein at least one of the components (1) to (3) is solid at room temperature. A particularly useful hydrophilic component in the system is a polymer that is solid at room temperature, e.g., solid PEG.

L'invention concerne une composition pharmaceutique à dispersion spontanée, comprenant un médicament faiblement soluble et un excipient composé (1) d'un élément lipophile, (2) d'un tensioactif et éventuellement (3) d'un élément hydrophile, l'élément lipophile et/ou l'élément hydrophile étant à l'état solide à température ambiante. Un élément hydrophile particulièrement utile dans le système peut être un polymère à l'état solide à température ambiante, tel que du PEG à l'état solide.

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