C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/215, 167/224
C07D 237/20 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 237/04 (2006.01) C07D 237/14 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2030133
ABSTRACT OF THE DISCLOSURE The invention relates to pyridazine derivatives of formula : Image (I) in which : -Ar represents a phenyl group substituted by R1 and R2 or a heterocyclic radical such as a pyridyl group, unsubstituted or substituted by methyl or methoxy, or a thienyl group, unsubstituted or substituted by chlorine, methyl or methoxy ; -R1 and R2 each independently denotes hydrogen, halogen, trifluoromethyl, hydroxyl, C1-C4 alkoxy or C1-C4 alkyl ; -R3 represents linear or branched C1-C4 alkyl, C3-C7 cycloalkyl, benzyl, phenethyl or the Ar' radical, Ar' being phenyl substituted by R1 and R2 ; -R4 represents : a Image group, with n = 0 or 1 in which X1 represents hydrogen or methyl ; -R5 represents a C1-C6 linear alkyl group ; -R6 represents a C1-C6 linear alkyl group, or R5 and R6 also constitute with the nitrogen atom to which they are attached a heterocycle selected from morpholine, pyrrolidine or piperidine ; as well as its salts with mineral or organic acids. The above compounds are useful as drugs, notably as drugs active on the cholinergic receptors of type M1.
Boigegrain Robert
Brodin Roger
Kan Jean Paul
Olliero Dominique
Wermuth Camille Georges
Sanofi
Sim & Mcburney
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