C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/26 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2369764
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules are useful as gene therapy agents for the treatment of diseases including post angioplasty restenosis, hypertension, atherosclerosis, heart failure, diabetes and diseases with defective angiogenesis. NOS proteins and peptides are also useful in methods of screening for agents which modulate NOS activity.
La présente invention concerne de nouveaux variants et mutants NOS qui contiennent des altérations structurelles dans le site de phosphorylation Akt dépendant. Les protéines ou les peptides NOS altérés, plus spécifiquement les protéines ou les peptides eNOS humains, les protéines ou les polypeptides Akt et leurs molécules d'acide nucléique de codage sont utiles en thérapie génique pour traiter des maladies telles que la resténose consécutive à une angioplastie, l'hypertension, l'athérosclérose, l'insuffisance cardiaque, le diabète et les maladies associées à un défaut d'angiogénèse. Les protéines et les peptides NOS sont également utiles dans des procédés de criblage d'agents qui modulent l'activité NOS.
Gowling Lafleur Henderson Llp
Yale University
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