Antibodies that specifically bind to tr2

Details Antibodies that specifically bind to tr2 Antibodies that specifically bind to tr2

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/44 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2482938

The present invention relates to antibodies and related molecules that specifically bind to TR2 proteins. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders, autoimmune disorders, immunodeficiencies and/or HSV infection. The invention also relates to nucleic acid molecules encoding anti-TR2 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments thereof, or related molecules, that specifically bind to TR2.

L'invention concerne des anticorps et à des molécules apparentées se liant spécifiquement à des protéines TR2. De tels anticorps sont utilisés, par exemple, dans la prévention et le traitement de cancers et autres troubles proliférants, troubles auto-immuns, immunodéficiences et/ou infections HSV. L'invention concerne également des molécules d'acide nucléique codant pour des anticorps anti-TR2, des vecteurs et des cellules hôtes contenant ces acides nucléiques, ainsi que des procédés de production de ceux-ci. L'invention concerne des procédés et des compositions destinées à la prévention, la détection, le diagnostic, le traitement ou l'amélioration d'une maladie ou d'un trouble, notamment du cancer et autres troubles hyperproliférants, comprenant l'administration à un animal, de préférence un être humain, d'une quantité efficace d'un ou de plusieurs anticorps ou fragments ou variants de ceux-ci, ou de molécules apparentées se liant spécifiquement à TR2.

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