Oligodendrocyte precursor cells and methods of obtaining and...

Details Oligodendrocyte precursor cells and methods of obtaining and... Oligodendrocyte precursor cells and methods of obtaining and...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/30 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12N 5/0793 (2010.01)

Patent

CA 2532216

The invention describes a self-renewing, phenotypically homogeneous population of oligodendrocyte precursor cells having a synchronized developmental stage and methods of obtaining a self-renewing phenotypically homogeneous population of oligodendrocyte precursor cells. Other methods include methods of maintaining and storing a homogeneous population of oligodendrocyte precursor cells for a prolonged period of time without change in the characteristics of the cells and methods of dedifferentiating oligodendrocyte precursor cells. The self-renewing, phenotypically homogeneous population of oligodendrocyte precursor cells or homogeneous population of oligodendrocytes may be useful for treating a patient having a CNS disorder or condition.

L'invention concerne une population autorenouvelée et phénotypiquement homogène de cellules précurseurs des olygodendrocytes ayant un stade de développement synchronisé, ainsi que des procédés pour son obtention. Elle concerne également d'autres procédés, notamment pour maintenir et stocker une population homogène de cellules précurseurs d'olygodendrocytes pendant une période prolongée sans modification des caractéristiques des cellules, ainsi que des procédés de dédifférentiation de cellules précurseurs des oligodendrocytes. La population autorenouvelée et phénotypiquement homogène de cellules précurseurs des oligodendrocytes ou bien la population homogène d'oligodendrocytes peuvent être utiles pour traiter un patient atteint d'un trouble ou d'un dérèglement du système nerveux central.

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