Process for the preparation of l-amino acids from their...

Details Process for the preparation of l-amino acids from their... Process for the preparation of l-amino acids from their...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12N 11/08 (2006.01) C12P 13/04 (2006.01)

Patent

CA 2379849

The invention relates to a method for the production of proteinogenic or non- proteinogenic L-amino acids, especially L-phosphinothricin, from their racemic N-acetyl-D,L-derivatives. The method is characterized in that: (a) N-acetyl-L- derivatives of the corresponding L-amino acids are selectively deacetylated by enzymatic racemate cleavage by means of isolated recombinant enzymes while the N-acetyl-D-derivatives of the corresponding D-amino acids are not deacetylated and (b) the deacetylated L-amino acids are preparatively separated from the non-deacetylated N-acetyl-D-derivatives and/or the incompletely deacetylated N- acetyl-L-derivatives.

L'invention concerne un procéde de fabrication d'acides aminés L protéinogènes ou non-protéinogènes, en particulier de phosphinothricine L, à partir de leurs dérivés-D,L-N-acétyliques racémiques. Ce procédé est caractérisé en ce que ; (a) des dérivés-L-N-acétyliques des acides aminés L correspondants sont déacétylés sélectivement par séparation racémique enzymatique au moyen d'enzymes recombinantes isolées, alors que des dérivés-D-N-acétylés des acides aminés D correspondants ne sont pas déacétylés ; et (b) les acides aminés L déacétylés obtenus sont séparés préparativement des dérivés-D-N-acétyliques non déacétylés et des dérivés-L-N-acétyliques partiellement déacétylés.

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