Truncated secretory aspartyl proteinase 2

Details Truncated secretory aspartyl proteinase 2 Truncated secretory aspartyl proteinase 2

C - Chemistry, Metallurgy

12

N

C12N 9/60 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2700055

The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.

La présente invention concerne une forme tronquée de l'aspartyle protéinase 2 sécrétée (Sap2), ainsi que des molécules d'acide nucléique codant pour celle-ci. Ce polypeptide Sap2 tronqué (tSap2) est étonnamment stable et dépourvu d'activité enzymatique. Cependant, il conserve son entière immunogénicité lors d'une administration intravaginale et confère une protection complète contre des infections intravaginales provoquées par la levure Candida. La présente invention porte en outre sur des compositions comportant tSap2 et sur l'utilisation de tSap2 dans la préparation de telles compositions.

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