Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2467916

The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention se rapporte à des composés d'azolopyrimidinone utilisés pour : traiter des maladies cellulaires proliférantes ; traiter des troubles associés à l'activité KSP de la kinésine ; et inhiber la kinésine KSP. L'invention se rapporte également à des compositions comprenant ces composés, ainsi qu'à leurs procédés d'utilisation dans le traitement du cancer chez des mammifères.

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