Process for 2-(aminoalkylthio)carbapenems

Details Process for 2-(aminoalkylthio)carbapenems Process for 2-(aminoalkylthio)carbapenems

C - Chemistry, Metallurgy

07

D

260/299

C07D 477/00 (2006.01)

Patent

CA 2002355

5557P/5033A 17455 TITLE OF THE INVENTION PROCESS FOR 2-(AMINOALKYLTHIO)CARBAPENEMS ABSTRACT OF THE INVENTION This invention relates to a process for preparing 2-(aminoalkylthio)carbapenems. In particular, this invention relates to a process in which a bis(substituted phenyl) phosphorohalidate is used to form an enol phosphate intermediate that can be converted to 2-(aminoalkylthio)carbapenems by reaction with suitable thioalkylamines.

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