Compositions and methods for treating and preventing...

Details Compositions and methods for treating and preventing... Compositions and methods for treating and preventing...

A - Human Necessities

61

K

A61K 31/77 (2006.01) A61K 31/765 (2006.01)

Patent

CA 2599219

The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188 - Pl 88) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)).

L'invention concerne des compositions et des méthodes permettant de traiter et de prévenir les maladies cardiaques. L'invention concerne, en particulier, des compositions comprenant des poloxamères (par exemple, le poloxamère 188 - Pl 88) et des méthodes utilisant lesdites compositions pour traiter et prévenir les maladies cardiaques (par exemple, chez les sujets souffrant d'une dystrophie musculaire) et pour traiter les dommages cellulaires et tissulaires provoqués par une ischémie et par la mort cellulaire (par exemple, pour traiter des cellules déficientes en dystrophine (par exemple, des myocytes)).

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