Methods and compositions for lowering the level of tumor...

Details Methods and compositions for lowering the level of tumor... Methods and compositions for lowering the level of tumor...

C - Chemistry, Metallurgy

12

N

C12N 15/864 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2374597

The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.

L'invention concerne des vecteurs de virus adéno-associé recombinés codant pour un antagoniste du facteur de nécrose tumorale (TNF). L'invention concerne également des techniques d'utilisation de ces vecteurs afin d'abaisser les niveaux du TNF chez un mammifère. L'invention concerne également des techniques d'utilisation de ces vecteurs de virus adéno-associé recombinés pour pallier les troubles associés au TNF.

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