Nitrooxy derivatives as angiotensin ii receptor antagonists

Details Nitrooxy derivatives as angiotensin ii receptor antagonists Nitrooxy derivatives as angiotensin ii receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) A61K 31/164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) C07D 257/04 (2006.01) C07D 403/10 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2745095

A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of -O-C 1-6 alkyl, -O-aryl, -O-heteroaryl, -O-C 3-8 cycloalkyl, -C 1-6 alkyl, -aryl, -heteroaryl, and -C 3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

Composé de structure où R est un groupement actif antagoniste de récepteur de l'angiotensine, et Y est choisi dans le groupe constitué par, R1 est choisi dans le groupe constitué par les groupements -O-(alkyle en C1-6), -O-aryle, -O-hétéroaryle, -O-(cycloalkyle en C3-8), -alkyle en C1-6, -aryle, -hétéroaryle et -cycloalkyle en C3-8 ; R2 et R3 sont indépendamment choisis dans le groupe constitué par l'hydrogène et les groupements alkyle en C1-4, ou l'un de ses sels ou hydrates de qualité pharmaceutique, pouvant être employé dans le traitement de l'hypertension.

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