Method of preparing an immunologically-active adjuvant-bound...

A - Human Necessities – 61 – K

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A61K 9/19 (2006.01) A61K 39/00 (2006.01) A61K 39/08 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2681567

The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an aluminum-salt adjuvant, a recombinant Clostridium botulinum neurotoxin protein and a glass-forming agent. These vaccine compositions are useful in the treatment of humans and other animals at risk of infection from Clostridium botulinum neurotoxin.

La présente invention concerne un procédé de préparation d'une composition de vaccin lyophilisée liée à un adjuvant immunologiquement actif. Un mode de réalisation spécifique fournit une composition de vaccin stable comprenant un adjuvant de type sel d'aluminium, une protéine recombinante de la neurotoxine de Clostridium botulinumet un agent formant un verre. Ces compositions de vaccin sont utiles dans le traitement d'humains et d'autres animaux risquant une infection par la neurotoxine de Clostridium botulinum.

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