Process for production of inhibited forms of activated blood...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/64 (2006.01) C07K 1/18 (2006.01) C07K 1/22 (2006.01) C07K 14/745 (2006.01) C07K 14/75 (2006.01) C12N 9/74 (2006.01) C12N 9/99 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2203807

A process, as shown in the figure, for producing a highly purified preparation of an inhibited form of an activated blood factor entails providing a partially purified preparation containing the blood factor of interest, treating the partially purified preparation to convert the blood factor to an inhibited activated form in a single step, and then purifiying the resulting inhibited activated blood factor.

L'invention concerne un procédé, comme illustré dans la figure, qui permet d'obtenir une preparation des plus pures d'une forme inhibée d'un facteur de coagulation sanguine, consistant à produire une préparation partiellement purifée contenant le facteur en question, à traiter cette préparation partiellement purifiée pour transformer en une seule étape le facteur de coagulation en une forme inhibée et, ensuite, à purifier le facteur activé inhibé qui en résulte.

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