Piperazine derivatives as 5-ht1a antagonists

Details Piperazine derivatives as 5-ht1a antagonists Piperazine derivatives as 5-ht1a antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 319/18 (2006.01) C07D 405/04 (2006.01) C07D 411/04 (2006.01)

Patent

CA 2124680

Compounds of formula (I) where A is a C1 or C2 alkylene chain optionally substituted by lower alkyl, Z is a bicyclic oxygen-containing radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl), R is hydrogen or lower alkyl, R1 is aryl or aryl(lower) alkyl and R2 and R3 are specified groups, and the pharmaceutically acceptable acid addition salts are novel. They are 5-HT1A- antagonists which may be used, for example, in treating anxiety.

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