Inhibitors of .beta.-lactamases and uses therefor

Details Inhibitors of .beta.-lactamases and uses therefor Inhibitors of .beta.-lactamases and uses therefor

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 33/22 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01)

Type

Patent

Patent number

CA 2291055

Description

The invention provides novel non-.beta.-lactam inhibitors of .beta.- lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with .beta.-lactam antibiotics to treat .beta.-lactam- antibiotic-resistant bacterial infections. These compounds are also antibacterial by themselves. Finally, the invention provides a pharmaceutical composition comprising these compounds.

L'invention concerne de nouveaux inhibiteurs, n'étant pas des .beta.-lactamines, de .beta.-lactamases. L'invention concerne en particulier des inhibiteurs constitués d'acides boroniques de la formule (1) présentée dans la description. Ces composés peuvent s'utiliser avec des antibiotiques à base de .beta.-lactamine dans le traitement d'infections bactériennes résistant aux antibiotiques à base de .beta.-lactamine. Ces composés sont eux-mêmes antibactériens. L'invention concerne enfin une composition pharmaceutique comprenant ces composés.

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