Substituted amidino compounds, their manufacture and methods...

Details Substituted amidino compounds, their manufacture and methods... Substituted amidino compounds, their manufacture and methods...

C - Chemistry, Metallurgy

07

C

C07C 257/10 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/44 (2006.01) C07C 257/18 (2006.01) C07C 257/20 (2006.01) C07C 271/64 (2006.01) C07C 311/51 (2006.01) C07C 323/42 (2006.01) C07D 211/16 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2148930

2148930 9411341 PCTABS00032 The invention relates to the compounds of formula (I) wherein the C( = NH)-NHR3 group may be in tautomeric or isomeric form, and pharmaceutically acceptable salts thereof, in which: R1 is amino which is mono- or disubstituted by a substituent selected from an aliphatic hydrocarbon radical, an araliphatic hydrocarbon radical, an aromatic radical, and a cycloaliphatic hydrocarbon radical or is amino which is disubstituted by a divalent aliphatic hydrocarbon radical or a said radical interrupted by oxygen; R2 is hydroxy which is etherified by an aliphatic alcohol which is substituted by carboxy, by esterified carboxy or by amidated carboxy; R3 is hydrogen or an acyl radical which is derived from an organic carbonic acid, an organic carboxylic acid, a sulfonic acid, or a carbamic acid; X1 and X3, independently of one another, are oxygen (-O-) or sulphur (-S-); and X2 is a divalent aliphatic hydrocarbon radical which may be interrupted by an aromatic radical. The compounds are useful as selective LTB4 receptor antagonists in the treatment of conditions or syndromes in mammals which are responsive to LTB4 receptor antagonism.

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