Preparation of 1,3-disubstituted imidazolium salts

C - Chemistry – Metallurgy – 07 – D

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C07D 233/56 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2079226

A process is disclosed for the preparation of a 1,3-disubstituted imidazolium salt having the following formula: (see formula 1) comprising contacting an .alpha.-dicarbonyl compound of formula (see formula 2) an aldehyde of the formula R2CHO, one or more amines of the formula R1NH2, and an acid of the formula H n X. Each R1 is hydrocarbyl, or substituted hydrocarbyl; R4 and R5 are each independently hydrogen, hydrocarbyl or substituted hydrocarbyl; X is an anion; and n is an integer corresponding to the number of anionic charges on X. The 1,3- disubstituted imidazolium salts are useful as synthetic intermediates, polymer precursors and pharmaceuticals.

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