Multi-gene expression vehicle

Details Multi-gene expression vehicle Multi-gene expression vehicle

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) A01H 5/00 (2006.01)

Patent

CA 2653404

A multigene expression vehicle (MGEV) consisting essentially of a polynucleotide comprising 2 to 8 domain segments, D, each domain encoding a functional protein, each domain being joined to the next in a linear sequence by a Linker (L) segment encoding a Linker peptide, the D and L segments all being in the same reading frame, and at least one of the domains is not a type two protease inhibitor.

Le véhicule d'expression multigénique (MGEV) faisant l'objet de cette invention est sensiblement constitué d'un polynucléotide qui comporte de 2 à 8 segments de domaine, D, chaque domaine codant pour une protéine fonctionnelle et étant relié au suivant en une séquence linéaire par un segment lieur (L) codant pour un peptide lieur. Les segments D et L sont tous situés dans le même cadre de lecture, et au moins l'un des domaines n'est pas un inhibiteur de protéase de type 2.

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