C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) C12N 9/88 (2006.01) C12Q 1/527 (2006.01)
Patent
CA 2339088
The present invention relates to the area of fatty acid oxidation, generally to compositions and methods of identifying and testing fatty acid oxidation inhibitors, and in particular, compositions comprising a novel cardiac isoform of MCD, identified to be a key regulator of fatty acid oxidation in the heart. Additionally, nucleotide acid sequences of malonyl CoA decarboxylase genes from the rat pancreas, heart and liver are described. Such sequences and derived products are useful in screening methods for identifying and testing agonists and antagonists of the MCD pathway.
L'invention concerne le domaine de l'oxydation des acides gras, des compositions et des procédés servant à identifier et à tester des inhibiteurs d'oxydation d'acides gras et, en particulier, des compositions contenant une nouvelle isoforme cardiaque de MCD, identifiée en tant que régulateur clé de l'oxydation des acides gras dans le coeur. Elle concerne, de plus, des séquences acides de nucléotides de gènes de malonyle CoA décarboxylase provenant du pancréas, du coeur et du foie du rat. Ces séquences et les produits dérivés sont utiles dans des procédés de criblage servant à identifier et à tester des agonistes et des antagonistes du trajet de MCD.
Dyck Jason
Lopaschuk Gary D.
Gowling Lafleur Henderson Llp
The Governors Of The University Of Alberta
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