Isomerisation of pharmaceutical intermediates

Details Isomerisation of pharmaceutical intermediates Isomerisation of pharmaceutical intermediates

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) C07B 37/08 (2006.01)

Patent

CA 2646856

The present invention relates to an isomerisation method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol, and to and to the use of a flow- through photoreactor or continuous flow photoreactor reactor for making said vitamin D analogues. The present invention relates further to the use of intermediates produced with said method for making calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.

La présente invention concerne une méthode d'isomérisation d'analogues de la vitamine D, tels que des composés pouvant être employés dans la synthèse du calcipotriol, ainsi que l'emploi d'un réacteur de type photoréacteur à écoulement ou photoréacteur à flux continu pour la fabrication desdits analogues de vitamine D. La présente invention concerne en outre l'emploi des intermédiaires produits par le biais de ladite méthode pour la fabrication du calcipotriol ou du calcipotriol monohydrate, ou des formules pharmaceutiques les incluant.

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