A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/14 (2006.01) B01J 13/00 (2006.01)
Patent
CA 2425906
The invention concerns a suspension of biocompatible particles for carrying active principles. Said carrier particles are based on a double-block hydrophilic neutral polyaminoacid/ hydrophobic neutral polyaminoacid copolymer. Said hydrophilic neutral polyaminoacid/ hydrophobic neutral polyaminoacid particles are capable of combining in colloidal suspension in non-dissolved state, at least an active principle and of releasing same, in particular in vivo, in prolonged and/or delayed delivery. The invention also concerns a powdery solid from which are derived the carrier particles and the preparation of said solid and of said suspension of active principle based on hydrophilic neutral polyaminoacids/ hydrophobic neutral polyaminoacids. Said carrier particles form spontaneously and in the absence of surfactants or organic solvents, stable aqueous suspensions. The invention also concerns the carrier particles in dry form, the method for preparing them, and pharmaceutical compositions (in dry form or suspension) comprising said carrier particles associated with an active principle.
L'invention concerne une suspension de particules biocompatibles de vectorisation (PV) de principes actifs (PA). Ces PV sont à base d'un copolymère dibloc polyaminoacide neutre hydrophile (polyAANI) / polyaminoacide neutre hydrophobe (polyAANO). Ces particules de polyAANI/polyAANO sont aptes à associer en suspension colloïdale à l'état non dissous, au moins un PA et à libérer celui-ci, notamment in vivo, de manière prolongée et/ou retardée. L'invention vise, également, un solide pulvérulent à partir duquel sont issues les PV ainsi que la préparation de ce solide et de cette suspension de PV à base de polyAANI/polyAANO. Ces nouvelles PV forment spontanément et sans l'aide de tensioactifs ou de solvants organiques, des suspensions aqueuses stables.L'invention concerne également les PV sous forme sèche, leur procédé de préparation, ainsi que des compositions pharmaceutiques (forme sèche ou suspension) comprenant ces PV associés à un principe actif.
Bryson Nathan
Soula Gerard
Flamel Technologies
Robic
LandOfFree
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